#Pts studied

Correlations found and/or comments

Goranova-Marinova (2007) [21]

66

At diagnosis

1. OPG levels higher in MM compared to HI 2. The OPG/creatinin ratio eliminated the difference 3. OPG levels correlared with b₂M and reversely with MBD^*

Martini (2006) [22]

26

At diagnosis

(smoldering myeloma)

OPG levels lower in MM compared to HI

Terpos (2005) [23]

35

Refractory (7) or relapsed (28) myeloma

1. OPG levels higher in MM before treatment compared to HI 2. The OPG/creatinin ratio eliminated the difference

Kraj (2005) [24]

133

1. OPG levels higher in MM compared to HI 2. OPG levels higher in pts with renal failure and hypercalcemia 3. OPG levels correlated with age, b₂M and bone marrow OPG concentrations

Depil (2005) [25]

140

At diagnosis 39 asymptomatic 101 mptomatic

1. OPG levels higher in MM compared to HI 2. No statistically significant difference between symptomatic and asymptomatic MM pts 3. OPG levels correlated with b₂M and creatinine 4. High OPG levels associated with a poorer survival

Corso (2004) [26]

103

39 at diagnosis 64 treated

OPG higher in MM and MGUS compared to HI.

Kyrtsonis (2004) [27]

32

27 at diagnosis 5 at remission

1. OPG levels higher in MM compared to HI OPG levels correlated with b₂M

Terpos (2004) [28]

51

4 at CR, 44 at PR 3 progressive/resistant

OPG levels lower in MM pre-ASCT compared to HI

Terpos (2003) [20]

121

At diagnosis

1. OPG levels lower in MM compared to HI 2. OPG levels correlared with b₂M, CRP and IL-6 levels, and inversely with MBD and serum markers of bone resorption

Seidel (2001) [29]

225

At diagnosis

1. OPG levels lower in MM compared to HI 2. OPG levels correlated with serum markers of bone formation and inversely with MBD and performance status